| 口服结肠靶向给药系统和制备方法的研究进展 |
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| 引用本文： | 吴庆喜,姚善泾. 口服结肠靶向给药系统和制备方法的研究进展[J]. 化工学报, 2013, 64(1): 210-222. DOI: 10.3969/j.issn.0438-1157.2013.01.023 |
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| 作者姓名： | 吴庆喜 姚善泾 |
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| 作者单位： | 浙江大学生物质化工教育部重点实验室,化学工程与生物工程学系,浙江 杭州 310027 |
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| 基金项目： | 国家自然科学基金重点项目，高等学校博士学科点专项基金重点项目 |
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| 摘 要： | 口服结肠靶向给药系统作为第四代药物剂型的发展和应用,具有靶向定位性、可提高局部药物浓度、直接作用于病变部位、降低药物剂量、减少副反应等优点,因而备受研究者的关注。本文针对口服结肠靶向给药系统的给药机理、应用和制备技术,综述了该领域近些年来的研究进展,为系统研究口服结肠靶向给药系统提供理论依据和参考。
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| 关 键 词： | 结肠靶向 给药系统 应用 制备 |
| 收稿时间： | 2012-04-26 |
| 修稿时间： | 2012-07-25 |
Oral colon-specific drug delivery system and its preparation |
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| WU Qingxi , YAO Shanjing. Oral colon-specific drug delivery system and its preparation[J]. Journal of Chemical Industry and Engineering(China), 2013, 64(1): 210-222. DOI: 10.3969/j.issn.0438-1157.2013.01.023 |
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| Authors: | WU Qingxi YAO Shanjing |
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| Affiliation: | Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China |
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| Abstract: | As the development and application of the fourth generation's drug dosage form, the oral colon-specific drug delivery system has the advantage of targeting orientation, increasing local drug concentration, acting on the lesion site directly, reducing drug dosage and side effect, etc.Aiming at the drug releasing mechanism, application and preparation technique, the research progress of this field is reviewed, so as to provide the theoretical basis and reference for the systematic research of the oral colon-specific drug delivery system. |
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| Keywords: | colon-specific drug delivery system application preparation |
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