| 新型(6-氯喹喔啉-2-基氧基)苯基丙烯酸酯和丙烯腈衍生物的设计、合成及生物活性 |
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| 引用本文： | 于春睿,徐龙鹤,吐松,李志念,李斌. 新型(6-氯喹喔啉-2-基氧基)苯基丙烯酸酯和丙烯腈衍生物的设计、合成及生物活性[J]. 农药, 2006, 45(9): 591-593 |
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| 作者姓名： | 于春睿 徐龙鹤 吐松 李志念 李斌 |
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| 作者单位： | 大连理工大学,精细化工国家重点实验室,辽宁,大连,116012;沈阳化工研究院,沈阳,110021;大连理工大学,精细化工国家重点实验室,辽宁,大连,116012;沈阳化工研究院,沈阳,110021 |
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| 摘 要： | 以2,6-二氯喹喔啉为起始原料、经Baylis—Hillman反应设计并合成了4个结构新颖的（6-氯喹喔啉-2-基氧基）苯基丙烯酸酯和丙烯腈衍生物，其结构经红外、核磁、元素分析确认。生物活性测定结果表明2-（（3-（6-氯喹喔啉-2-基氧）苯基）（羟基）甲基）丙烯酸甲酯（3a）和2-（（4-（6-氯喹喔啉-2．基氧）苯基）（羟基）甲基）丙烯腈（3d）具有有效的杀菌活性，在400ga．i．／hm^2的剂量下对黄瓜霜霉病的防效分别为100％和75％。
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| 关 键 词： | 合成 生物活性 (6-氯喹喔啉-2-基氧基)苯基丙烯酸酯和丙烯腈 Baylis-Hillman加成物 |
| 文章编号： | 1006-0413（2006）09-0591-03 |
| 收稿时间： | 2006-04-10 |
| 修稿时间： | 2006-04-10 |
Design, synthesis and biological activity of novel (6-chloroquinoxalin-2-yloxy) phenylacrylate and acrylonitrile derivatives |
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| YU Chun-rui,XU Long-he,TU Song,LI Zhi-nian,LI Bin. Design, synthesis and biological activity of novel (6-chloroquinoxalin-2-yloxy) phenylacrylate and acrylonitrile derivatives[J]. Pesticides, 2006, 45(9): 591-593 |
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| Authors: | YU Chun-rui XU Long-he TU Song LI Zhi-nian LI Bin |
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| Affiliation: | 1.State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, Liaoning, China; 2.Shenyang Research Institute of Chemical Industry, Shenyang 110021, China |
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| Abstract: | Four novel (6-chloroquinoxalin-2-yloxy)phenyl acrylate and acrylonitrile derivatives were designed and synthesized utilizing 2,6-dichloroquinoxaline as a starting material via Baylis-Hillman reaction. Their structures were confirmed by IR, 1H NMR and elemental analyses. Evaluation of their biological activities showed that methyl 2-((3- (6-chloroquinoxalin-2-yloxy)phenyl)(hydroxy)methyl) acrylate (3a) and 2-((4-(6-chloroquinoxalin-2-yloxy)phenyl) (hydroxy)methyl) acrylonitrile (3d) exhibited efficient fungicidal activity, with 100% and 75% control of cucumber downy mildew (CDM) respectively at 400 g a.i./ha. |
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| Keywords: | synthesis biological activity (6-chloroquinoxalin-2-yloxy)phenylacrylate and acrylonitrile Baylis-Hillman adduct |
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