Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity |
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| Authors: | CH K?hne P Thuss-Patience M Friedrich PT Daniel A Kretzschmar T Benter B Bauer R Dietz B D?rken |
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| Affiliation: | Department of Haematology/Oncology and Tumor Immunology Robert-R?ssle-Klinik, Virchow-Klinikum, Medizinische Fakult?t Charite der Humboldt-Universit?t zu Berlin, Germany. |
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| Abstract: | Two patients with proven 5-fluorouracil (5-FU)-associated cardiotoxicity were treated with the specific thymidylate synthase inhibitor raltitrexed safely, without evidence of cardiotoxicity. Raltitrexed might be an alternative for patients with advanced colorectal cancer and 5-FU-associated cardiotoxicity. 5-FU cardiotoxicity is not due to the antineoplastic mechanisms via thymidilate synthase. |
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