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Organofluorine Hydrazone Derivatives as Multifunctional Anti-Alzheimer's Agents with CK2 Inhibitory and Antioxidant Features |
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| Authors: | Prof Andrea Baier Dr Anne Kokel Dr William Horton Ewa Gizińska Dr Garima Pandey Prof Ryszard Szyszka Prof Béla Török Prof Marianna Török |
| Affiliation: | 1. Department of Animal Physiology and Toxicology, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland;2. Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA, 02125 USA;3. Department of Molecular Biology, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland |
| Abstract: | A set of novel hydrazone derivatives were synthesized and analyzed for their biological activities. The compounds were tested for their inhibitory effect on the phosphorylating activity of the protein kinase CK2, and their antioxidant activity was also determined in three commonly used assays. The hydrazones were evaluated for their radical scavenging against the DPPH, ABTS and peroxyl radicals. Several compounds have been identified as good antioxidants as well as potent protein kinase CK2 inhibitors. Most hydrazones containing a 4-N(CH3)2 residue or perfluorinated phenyl rings showed high activity in the radical-scavenging assays and possess nanomolar IC50 values in the kinase assays. |
| Keywords: | Alzheimer's disease antioxidants hydrazones organofluorine protein kinase CK2 radical scavenging |