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Aliphatic 18F-Radiofluorination: Recent Advances in the Labeling of Base-Sensitive Substrates** |
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| Authors: | Dr. Klas Bratteby Dr. Vladimir Shalgunov Prof. Matthias Manfred Herth |
| Affiliation: | 1. Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 160, 2100 Copenhagen, Denmark Department of Radiation Physics, Skåne University Hospital, Barngatan 3, 222 42 Lund, Sweden Department of Clinical Physiology, Nuclear Medicine & PET Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark;2. Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 160, 2100 Copenhagen, Denmark |
| Abstract: | Aliphatic fluorine-18 radiolabeling is the most commonly used method to synthesize tracers for PET-imaging. With an increasing demand for 18F-radiotracers for clinical applications, new labeling strategies aiming to increase radiochemical yields of established tracers or, more importantly, to enable 18F-labeling of new scaffolds have been developed. In recent years, increased attention has been focused on the direct aliphatic 18F-fluorination of base-sensitive substrates in this respect. This minireview gives a concise overview of the recent advances within this field and aims to highlight the advantages and limitations of these methods. |
| Keywords: | fluorine-18 radiochemistry base sensitivity aliphatic SN2 |