| 以( )-脱氢枞胺为原料合成( )-弥罗松酚 |
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| 引用本文： | 周志,林中祥,蔡凌云. 以( )-脱氢枞胺为原料合成( )-弥罗松酚[J]. 精细化工, 2015, 32(3): 353-356 |
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| 作者姓名： | 周志 林中祥 蔡凌云 |
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| 作者单位： | 1. 凯里学院化学与材料工程学院,贵州凯里,556011
2. 南京林业大学化学工程学院,江苏南京,210037 |
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| 基金项目： | 国家自然科学基金项目（面上项目);凯里学院博士专项课题资助项目 |
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| 摘 要： | 报道了以(+)-脱氢枞胺为起始原料,通过两条路线合成生物活性的二萜化合物(+)-弥罗松酚。路线(1):(+)-脱氢枞胺在羟氨-O-磺酸和氢氧化钠作用下还原脱氨生成脱氢松香烷,再经Friedele-Crafts乙酰化、BaeyerVilliger氧化、水解生成(+)-弥罗松酚,总产率29.5%。路线(2):(+)-脱氢枞胺还原脱氨,然后与过氧化邻苯二甲酰反应得到(+)-弥罗松酚,总产率31.9%。
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| 关 键 词： | 二萜 弥罗松酚 脱氢枞胺 精细化工中间体 |
| 收稿时间： | 2014-09-14 |
| 修稿时间： | 2014-12-14 |
Synthesis of ( )-ferruginol from ( )-dehydroabietylamine |
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| ZHOU Zhi,LIN Zhong-xiang and CAI Ling-yun. Synthesis of ( )-ferruginol from ( )-dehydroabietylamine[J]. Fine Chemicals, 2015, 32(3): 353-356 |
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| Authors: | ZHOU Zhi LIN Zhong-xiang CAI Ling-yun |
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| Affiliation: | Kaili University,Nanjing Forestry University,Kaili University |
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| Abstract: | Two new synthetic routes to bioactive diterpene compound ( )-ferruginol starting from ( )-dehydroabietylamine were reported. Route 1: The reductive deamination of ( )-dehydroabietylamine with hydroxylamine-o-sulfonic acid and sodium hydroxide yielded dehydroabietane, followed by Friedel-Crafts acylation, Baeyer-Villiger oxidation and hydrolysis, gave ( )-ferruginol in 29.5% overall yield. Route 2: The reductive deamination of ( )-dehydroabietylamine, then reacted with phthaloyl peroxide to give ( )-ferruginol, overall yield 31.9%. |
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| Keywords: | diterpene ferruginol dehydroabietylamine synthesis |
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