PVA-SA复合微球的制备及性能研究

用溶液共混法制备聚乙烯醇-海藻酸钠(PVA-SA)复合微球,考察了SA质量分数、PVA质量分数、CaCl2质量分数、m(PVA)/m(SA)和干燥方式对PVA-SA复合微球制备的影响,并测定了微球的含水率、溶胀率、载药量和包封率,通过红外光谱(FTIR)对微球进行了表征,研究了不同m(PVA)/m(SA)的PVA-SA复合微球对药物的缓释作用。结果表明,SA质量分数为6%,PVA质量分数为10%,CaCl2质量分数为5%,m(PVA)/m(SA)为1∶3时,可以制备出各项性能较好的微球,其载药率30.24%,包封率90.11%,并且有良好的缓释效果。

Preparation and Properties of Blend Microspheres of Polyvinyl Alcohol and Sodium Alginate

Novel PVA-SA based microspheres,prepared by polymers solution blending method,were developed for the delivery of drug.The parameters such as the concentration of SA,PVA and CaCl2,mass ratio of PVA to SA and dry method were adjusted to improve the properties of blend microspheres.The water content,swelling rate,drug loading rate,entrapment efficiency and PTIR analysis were carried out to characterize the composite microspheres.The effects of the ratio of PVA to SA of blend microspheres on the sustained release behavior were also discussed.The results show that,when SA concentration is 6%,PVA concentration is 10% and CaCl2 concentration is 5%,and the mass ratio of PVA and SA is 1∶3,blend microspheres with excellent properties can be prepared.The microspheres have high drug loading rate of 30.24%,entrapment efficient of 90.11%,good sustained release behavior and may be used as a special drug delivery system.