| 2-甲基-3-喹啉甲酸的酯化反应研究 |
| |
| 引用本文： | 张朝花,高峰,李阳,高文涛. 2-甲基-3-喹啉甲酸的酯化反应研究[J]. 广州化工, 2009, 37(8): 80-81,87 |
| |
| 作者姓名： | 张朝花 高峰 李阳 高文涛 |
| |
| 作者单位： | 渤海大学超精细化学品研究所,辽宁,锦州,121000;渤海大学超精细化学品研究所,辽宁,锦州,121000;渤海大学超精细化学品研究所,辽宁,锦州,121000;渤海大学超精细化学品研究所,辽宁,锦州,121000 |
| |
| 基金项目： | 辽宁省高校重点实验室计划项目(2008S001)资助 |
| |
| 摘 要： | 以2－甲基－3-喹啉甲酸为原料，在浓硫酸作为催化剂的条件下与乙醇发生酯化反应合成了标题化合物。对它的合成工艺条件进行了探索和优化，优化的最佳反应条件是2－甲基－3－喹啉甲酸，乙醇和浓硫酸的投料比为1．0mmol：1mL：0．2mL；反应时间为2h，收率为68．1％。优化后的合成方法具有反应时间短、产率较高等优点。
|
| 关 键 词： | 酯化 2-甲基-3-喹啉甲酸 正交实验 合成 |
Study on Esterification Reaction of 2-Methylquinoline-3-carboxylic Acid |
| |
| ZHANG Chao-hua,GAO Feng,LI Yang,GAO Wen-tao. Study on Esterification Reaction of 2-Methylquinoline-3-carboxylic Acid[J]. GuangZhou Chemical Industry and Technology, 2009, 37(8): 80-81,87 |
| |
| Authors: | ZHANG Chao-hua GAO Feng LI Yang GAO Wen-tao |
| |
| Affiliation: | Institute of Superfine Chemicals;Bohai University;Liaoning Jinzhou 121000;China |
| |
| Abstract: | The esterification reaction of 2-methylquinoline-3-carboxylic acid in the solvent of ethanol with concentrated H2SO4 as catalyst was studied.The reaction condition was optimized and the best results could be achieved when the esterification reaction was conducted in the ratio of 2-methyl-3-quinolinic acid,ethanol and concentrated H2SO41.0 mmol:1.0 mL:0.2 mL for 2h.The yield of the product could reach 68.1% under the optimal reaction conditions.The advantages of the optimal methodology were shorter reaction ... |
| |
| Keywords: | esterification 2-methylquinoline-3-carboxylic acid orthogonal experiment synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
