| 烷化核酸碱基结构的特征研究 |
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| 引用本文： | 徐维并,佟柏龄.烷化核酸碱基结构的特征研究[J].现代仪器,2002,8(6):26-28. |
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| 作者姓名： | 徐维并 佟柏龄 |
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| 作者单位： | 中国科学院生态环境研究中心,北京,100085;国家地质实验测试中心,北京,100037 |
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| 摘 要： | 采用FTIR、HPLC和 GC-MS等分析手段研究大气环境中典型污染物苯并(a)芘与DNA碱基鸟嘌呤加合物的结构特征,首次测定苯并(a)芘等与鸟嘌呤加合物的红外光谱,加合反应后,烷化核酸碱基红外振动峰的峰形、峰位都发生明显变化。为进一步分子水平研究烷化核酸碱基类加合物提供依据。
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| 关 键 词： | 苯并(a)芘 鸟嘌呤 加合物 红外光谱 |
Study on structure characteristics of alkylated nucleic acid bases |
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| Xu Weibing Tong Bailing.Study on structure characteristics of alkylated nucleic acid bases[J].Modern Instruments,2002,8(6):26-28. |
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| Authors: | Xu Weibing Tong Bailing |
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| Abstract: | In This paper the adducts were characterized by IR、UV and MS. The experimental results indicated that there Determination of guanine adduct isomers by high performance liquid chromatography (HPLC),and Fourier-transform infrared (FTIR) spectrometry. The IR spectra of alkylated nucleic acid bases are quite different. The group at 1600 cm~(-1) was weakend in IR spectra. The experimental results show that the UV spectra of adducts of Pyrene-Guanine are similar between 305-340 nm. |
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| Keywords: | Benzo(a)pyrene Guanine Adduct FTIR |
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