Specific serological diagnosis of leprosy with a recombinant Mycobacterium leprae protein purified from a rapidly growing mycobacterial host |
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Authors: | JA Triccas PW Roche WJ Britton |
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Affiliation: | Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia. jtriccas@pasteur.fr |
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Abstract: | In this report we demonstrate the utility of an monoclonal antibody inhibition enzyme-linked immunosorbent assay based on the Mycobacterium leprae 35-kDa protein, purified from the rapidly growing host Mycobacterium smegmatis, for the serodiagnosis of multibacillary leprosy. The assay proved highly specific (97.5%) and sensitive (90%) and compared favorably with two other established methods routinely utilized for leprosy serodiagnosis. |
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