Synthesis of novel monomeric cyanine dyes containing mercapto and thioacetyl substituents for nucleic acid detection期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis of novel monomeric cyanine dyes containing mercapto and thioacetyl substituents for nucleic acid detection

Authors:	Todor Deligeorgiev Nikolai Gadjev Aleksey Vasilev Karl-Heinz Drexhage S.M. Yarmoluk

Affiliation:	^aUniversity of Sofia, Faculty of Chemistry, 1164 Sofia, Bulgaria ^bUniversity of Siegen, Department of Chemistry, D-57068 Siegen, Germany ^cInstitute of Molecular Biology and Genetics, National Academy of Science of Ukraine, 150 Zabolotnogo Street, 03143 Kyiv, Ukraine

Abstract:	Fifteen novel mono-, di- and tricationic monomeric monomethine cyanine dyes, bearing mercapto and thioacetyl substituents, useful for nucleic acid detection are described. All derivatives absorb in the region 417–508 nm and have molar absorptivities of 61 000–101 300 l mol⁻¹ cm⁻¹. The products were characterized by ¹H NMR, HPLC–MS and elemental analysis.

Keywords:	Monomeric Cationic monomethine cyanine dyes Mercapto Thioacetyl substituents Nucleic acids
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