Ion Channels and Transporters in Muscle Cell Differentiation |
| |
Authors: | Lingye Chen Fatemeh Hassani Nia Tobias Stauber |
| |
Affiliation: | 1.Institute for Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany;2.Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China;3.Institute for Molecular Medicine, MSH Medical School Hamburg, 20457 Hamburg, Germany; |
| |
Abstract: | Investigations on ion channels in muscle tissues have mainly focused on physiological muscle function and related disorders, but emerging evidence supports a critical role of ion channels and transporters in developmental processes, such as controlling the myogenic commitment of stem cells. In this review, we provide an overview of ion channels and transporters that influence skeletal muscle myoblast differentiation, cardiac differentiation from pluripotent stem cells, as well as vascular smooth muscle cell differentiation. We highlight examples of model organisms or patients with mutations in ion channels. Furthermore, a potential underlying molecular mechanism involving hyperpolarization of the resting membrane potential and a series of calcium signaling is discussed. |
| |
Keywords: | bioelectricity calcium signaling cardiac differentiation membrane potential myoblast differentiation stem cells vascular remodeling |
|
|