| Abstract: | In order to apply a blood-compatible polymer to hemodialysis membrane, a new polyether-segmented nylon which dissolved in common organic solvents was designed. The basic polyether-segmented nylon was synthesized by melt polycondensation from sebacic acid, m-xylenediamine, and α,ω-bisaminopropyl-poly(ethylene oxide). To improve the solubility, azelaic acid and hexamethylenediamine were copolycondensed with the basic copolymer. The solubility was correlated with the heat of fusion (ΔHm) of the copolymer. When ΔHm is < 30 mJ/mg, the polymer is soluble in dimethylsulfoxide and makes a stable solution. The nonthrombogenicity was investigated in the viewpoint of adhesion of platelet onto the copolymer surface. It is made clear that the surface of the block copolymer, having > 10 wt % of poly(ethylene oxide), suppresses the adhesion of platelet, and the composition of the nylon block has no effect on the adhesion of platelet. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 65:1723–1729, 1997 |
