The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases |
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| Authors: | Monika Zaborek-Ł yczba,Jakub Ł yczba,Paulina Mertowska,Sebastian Mertowski,Anna Hymos,Martyna Podgajna,Paulina Niedź wiedzka-Rystwej,Ewelina Grywalska |
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| Affiliation: | 1.Department of Experimental Immunology, Medical University of Lublin, 4a Chodzki Street, 20-093 Lublin, Poland; (M.Z.-Ł.); (J.Ł.); (P.M.); (S.M.); (A.H.); (M.P.);2.Institute of Biology, University of Szczecin, 3c Felczaka Street, 71-412 Szczecin, Poland |
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| Abstract: | The human G-leukocyte antigen (HLA-G) molecule is a non-classical major histocompatibility complex (MHC) class I molecule. The pertinence of HLA-G has been investigated in numerous studies which have sought to elucidate the relevance of HLA-G in pathologic conditions, such as autoimmune diseases, cancers, and hematologic malignancies. One of the main goals of the current research on HLA-G is to use this molecule in clinical practice, either in diagnostics or as a therapeutic target. Since HLA-G antigens are currently considered as immunomodulatory molecules that are involved in reducing inflammatory and immune responses, in this review, we decided to focus on this group of antigens as potential determinants of progression in autoimmune diseases. This article highlights what we consider as recent pivotal findings on the immunomodulatory function of HLA-G, not only to establish the role of HLA-G in the human body, but also to explain how these proteins mediate the immune response. |
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| Keywords: | autoimmune diseases human G-leukocyte antigen (HLA-G) major histocompatibility complex (MHC) |
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