| 硫化氢对阿尔茨海默病的保护作用研究进展 |
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| 引用本文： | 魏海军,张庆丽,王玥,胡亚,赵美. 硫化氢对阿尔茨海默病的保护作用研究进展[J]. 湖南生态科学学报, 2021, 8(1): 89-94. DOI: 10.3969/j.issn.2095-7300.2021.01.013 |
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| 作者姓名： | 魏海军 张庆丽 王玥 胡亚 赵美 |
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| 作者单位： | 湖南环境生物职业技术学院 医学院,湖南 衡阳 421005 |
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| 基金项目： | 湖南省自然科学青年基金项目(2020JJ5147);湖南省教育厅科学研究一般项目(19C0650);湖南省卫生健康委一般资助课题(202102011100)。 |
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| 摘 要： | 硫化氢的生物学作用广泛,在心血管系统、神经系统、糖尿病等疾病中都起到重要的调节作用,特别是对阿尔茨海默病具有至关重要的保护作用.阿尔茨海默病是中枢神经系统中一种常见的神经退行性疾病,目前尚未研究出理想的临床治疗药物,而内源性硫化氢稳态的失调与阿尔茨海默病的病理进程有关.本文概述了硫化氢在阿尔茨海默氏病中的保护作用,其机...
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| 关 键 词： | 硫化氢 阿尔茨海默病 保护作用 研究进展 |
Research Progress on Protective Effect of Hydrogen Sulfide onAlzheimer's Disease |
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| WEI Haijun,ZHANG Qingli,WANG Yue,HU Ya,ZHAO Mei. Research Progress on Protective Effect of Hydrogen Sulfide onAlzheimer's Disease[J]. Journal of Hunan Ecological Science, 2021, 8(1): 89-94. DOI: 10.3969/j.issn.2095-7300.2021.01.013 |
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| Authors: | WEI Haijun ZHANG Qingli WANG Yue HU Ya ZHAO Mei |
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| Affiliation: | (Medical Department,Hunan Polytechnic of Environment and Biology,Hengyang 421005,China) |
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| Abstract: | Hydrogen sulfide has a wide range of biological effects,and plays an important regulatory role in cardiovascular system,nervous system,diabetes and other diseases,especially for Alzheimer's dis?ease.Alzheimer’s disease is a common neurodegenerative disease in the central nervous system.The ide?al clinical treatment drug has not yet been developed,and the imbalance of endogenous hydrogen sulfide homeostasis is related to the pathological process of Alzheimer’s disease.This review summarizes the pro?tective effects of hydrogen sulfide on Alzheimer's disease,including its antioxidant,anti-apoptotic and anti-inflammatory effects,as well as its relationship with up regulating the expression of silent informa?tion regulator 1 and enhancing the expression of longevity gene korosol.It provides a research basis for hy?drogen sulfide to become a new method for the treatment of Alzheimer's disease. |
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| Keywords: | Hydrogen sulfide Alzheimer's disease protective effect research progress |
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