海藻多糖与肠道菌群相互作用研究进展

肠道菌群是寄居于宿主体内的共生微生物群体, 在维持机体健康及控制疾病发生等方面发挥着重要作用。海藻多糖是从海藻中提取出的一种具有生物活性的膳食纤维, 具有抗肿瘤、抗氧化、抗病毒、降血糖、免疫调节等多种活性。研究发现海藻多糖不能被人体消化酶降解, 但可以被肠道菌群降解和利用, 而海藻多糖又可以通过调节肠道菌群影响机体健康。本文综述了肠道菌群对海藻多糖的降解利用, 海藻多糖通过调节肠道菌群改善炎症性肠病、高血脂、糖尿病等疾病, 探讨了海藻多糖结构对肠道菌群的影响, 以期为海藻多糖与肠道菌群相互作用在改善人体健康方面的研究提供一定参考。

Research progress on interaction of seaweed polysaccharides with intestinal flora

Intestinal flora is a symbiotic microbial population that residency in the host, which plays a vital role in maintaining health and treating diseases. Seaweed polysaccharides is a class of biologically active dietary fiber, which is extracted from seaweed and displayed a wide range of biological activities, including anti-tumor, anti-oxidation, anti-virus, immunomodulatory, hypoglycemic and so on. Studies have found that seaweed polysaccharide are non-digestible by digestive enzymes in the body, but can be degraded and fermented by intestinal flora. The seaweed polysaccharide could also affect human health by regulating intestinal flora. This paper reviewed the degradation and utilization of intestinal flora on seaweed polysaccharides, the modulatory effects of seaweed polysaccharides on gut flora to alleviate diseases, such as inflammatory bowel disease, hyperlipidemia and diabetes mellitus, and discussed the effects of seaweed polysaccharides structure on intestinal flora, hoping to provide references for the study of bidirectional effects of seaweed polysaccharides and intestinal fiora in improving human health.