|
|||||
|
|
Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism,as a Model for HIV Infection |
|
| Authors: | Dr. Christopher R. M. Asquith Prof. Tuomo Laitinen Dr. Lidia S. Konstantinova Dr. Graham Tizzard Prof. Antti Poso Prof. Oleg A. Rakitin Prof. Regina Hofmann-Lehmann Dr. Stephen T. Hilton |
| Affiliation: | 1. School of Pharmacy, Faculty of Life Sciences, University College London, London, WC1N 1AX UK;2. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, 70211 Finland;3. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991 Russian Federation Nanotechnology Education and Research Center, South Ural State University, Lenina Ave. 76, Chelyabinsk, Russian Federation;4. UK National Crystallography Service, School of Chemistry, University of Southampton, Highfield Campus, Southampton, SO17 1BJ UK;5. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991 Russian Federation;6. Clinical Laboratory & Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland |
| Abstract: | A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity. |
| Keywords: | 1,2,3,4,5-pentathiepin antiviral agents FIV HIV nucleocapsid protein varacin |