Conjugation of Dasatinib with MHI-148 Has a Significant Advantageous Effect in Viability Assays for Glioblastoma Cells |
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Authors: | Dr Syed Muhammad Usama Dr Zhengyang Jiang Kathryn Pflug Dr Raquel Sitcheran Dr Kevin Burgess |
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Affiliation: | 1. Department of Chemistry, Texas A&M University, Box 30012, College Station, TX, 77842 USA;2. Department of Molecular & Cellular Medicine, Texas A&M University Health Science Center, College Station, TX, 77843 USA |
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Abstract: | We hypothesized that conjugation of the near-infrared dye MHI-148 with the anti-leukemia drug dasatinib might produce a potential theranostic for glioblastoma. In fact, the conjugate was found to bind the kinases Src and Lyn, and to inhibit the viability of a glioblastoma cell line with significantly greater potency than dasatinib alone, MHI-148 alone, or a mixture of dasatinib and MHI-148 at the same concentration. It was also used to successfully image a subcutaneous glioblastoma tumor in vivo. |
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Keywords: | cancer cyanine glioblastoma imaging agents tumor targeting |
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