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A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid |
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| Authors: | Dr Sónia Teixeira Dr Miguel M Santos Prof Ricardo Ferraz Prof Cristina Prudêncio Prof Maria H Fernandes Prof João Costa-Rodrigues Dr Luís C Branco |
| Affiliation: | 1. Faculdade de Medicina Dentária, Universidade do Porto, Rua Dr. Manuel Pereira da Silva, Porto, Portugal;2. Department of Chemistry, LAQV-REQUIMTE, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, Caparica, Portugal;3. Ciências Químicas e das Biomoléculas/Centro de Investigação em Saúde e Ambiente (CISA), ESS-Escola Superior de Saú de do Porto do Instituto Politécnico do Porto, Porto, Portugal;4. Faculdade de Medicina Dentária, Universidade do Porto, Rua Dr. Manuel Pereira da Silva, Porto, Portugal
ESS-Escola Superior de Saúde, Porto, Portugal Instituto Politécnico de Viana do Castelo, Escola Superior de Saúde, Porto, Portugal |
| Abstract: | Novel ionic liquids and organic salts based on mono- or dianionic zoledronate and protonated superbases, choline and n-alkylmethylimidazolium cations, were prepared and characterized by spectroscopic and thermal analyses. Most of the prepared salts display amorphous structures and very high solubility in water and saline solutions, especially the dianionic salts. Among the zoledronate-based ionic compounds, those containing choline Ch] and methoxyethylmethylimidazolium C3OMIM] cations appear to have significant cytotoxicity against human osteosarcoma cells (MG63) and low toxicity toward healthy skin fibroblast cells. Because osteosarcoma is a bone pathology characterized by an increase in bone turnover rate, the results presented herein may be a promising starting point for the development of new ionic pharmaceutical drugs against osteosarcoma. |
| Keywords: | API-OSIL bioavailability cytotoxicity ionic liquids zoledronic acid |