Report of four cases of lymphocytic infundibuloneurohypophysitis |
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Authors: | Y Iwai K Yamanaka K Yoshioka Y Okamoto T Sato |
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Affiliation: | The Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel. |
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Abstract: | Multiple injections of intact irradiated BCL1 cells, a murine B-cell leukemia/lymphoma can trigger a dose-dependent anti-tumor immune response in naive syngeneic mice. The ability to induce anti-BCL1 immunity and the effect of various cell-modifications on BCL1 tumorigenicity and immunogenicity was evaluated. Newcastle disease virus (NDV) infection or transfer of cytokine genes by both retroviral and Adeno 5 vectors affect neither tumorigenicity nor immunogenicity of BCL1 cells given as a non-immunogenic cell-dose. New ways will have to be developed to elicit a reliable and reproducible anti-tumor effect in spontaneously arising and non-immunogenic hematological malignancies. |
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