Collection and transfusion of blood and blood components in the United States, 1989 |
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Authors: | EL Wallace DM Surgenor HS Hao J An RH Chapman WH Churchill |
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Affiliation: | Istituto Nazionale Neurologico C. Besta, Milan, Italy. |
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Abstract: | A poor response to L-DOPA in addition to parkinsonian, cerebellar, and autonomic signs is commonly regarded as indicative of clinical multiple system atrophy (MSA). We compared the motor response to a single oral administration of 250 mg L-DOPA/25 mg carbidopa in eight MSA patients and eight Parkinson's disease (PD) patients with the "on-off" phenomenon, evaluating L-DOPA peripheral pharmacokinetics. Motor response was consistently good in all PD patients, but only four MSA patients had a (moderate) response. Pharmacokinetic parameters did not differ between the groups. The varying extent of putaminal damage could be responsible for the differing motor response to L-DOPA in MSA patients. |
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