| 安多霖对高功率微波照射大鼠性激素和氧化还原系统的影响 |
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| 引用本文： | 郝述霞,王春燕,齐雪松,张伟,张翠兰,吕慧敏.安多霖对高功率微波照射大鼠性激素和氧化还原系统的影响[J].辐射防护,2011,31(5). |
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| 作者姓名： | 郝述霞 王春燕 齐雪松 张伟 张翠兰 吕慧敏 |
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| 作者单位： | 中国疾病预防控制中心辐射防护与核安全医学所,北京,100088 |
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| 摘 要： | 选用SD和Wistar大鼠为研究模型。将SD大鼠分为对照组、模型组、6和12 g/kg给药组,给药组动物安多霖连续灌胃30天,100 mW/cm2微波全身照射10分钟,照后24小时取全血分离血清,放射免疫法检测血清睾酮和卵泡刺激素（FSH）活性。将Wistar大鼠分为模型组、3、6和9 mg/kg给药组,给药组动物安多霖连续给药7天,以100 mW/cm2微波照射15分钟,照后继续给药至照后3、7和10天,取血分离血清,分光光度法检测血清过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）活性和还原型谷胱甘肽（GSH）含量。结果显示,照后SD雄性大鼠血清睾酮含量较对照组显著降低（p〈0.05）,但给药组降低的幅度低于模型组,如12g/kg组与对照组之间无明显差异。从CAT、GSH-Px和GSH的分析结果看,安多霖可不同程度地提高Wistar大鼠血清CAT、GSH-Px活性和GSH含量,尤其是照后7天,6和9 mg/kg给药组GSH-Px活性较模型组有明显的提升（p〈0.05）。从以上结果可以得出,安多霖对微波辐射损伤的大鼠具有一定的保护作用。
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| 关 键 词： | 高功率微波 安多霖 睾酮 GSH CAT GSH-Px FSH |
Impact of Anduolin on Rat Sex Hormones and Redox System Exposed to High Power Microwave Radiation |
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| Hao Shuxia,Wang Chunyan,Qi Xuesong,Zhang Wei,Zhang Cuilan,Lu Huimin.Impact of Anduolin on Rat Sex Hormones and Redox System Exposed to High Power Microwave Radiation[J].Radiation Protection,2011,31(5). |
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| Authors: | Hao Shuxia Wang Chunyan Qi Xuesong Zhang Wei Zhang Cuilan Lu Huimin |
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| Affiliation: | Hao Shuxia,Wang Chunyan,Qi Xuesong,Zhang Wei,Zhang Cuilan,Lu Huimin(National Institute for Radiological Protection,China CDC,Beijing 100088) |
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| Abstract: | SD and Wistar rats were used as research models.SD rats were divided into control group, model group,6 and 12 g/kg treatment groups,the SD rats were irradiated with microwave of 100 mW/ cm2for 10 min after 30 days prophylaxis and serum were taken 1 day after irradiated.Testosterone(T) and follicle stimulating hormone(FSH) were detected with radioimmunoassay.The Wistar male rats were divided into model group,3,6 and 9 mg/kg drug groups,the rats were irradiated with microwave of 100 mW/cm2for 15 min after 7 d... |
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| Keywords: | High Power Microwave Anduolin Catalase Glutathione Peroxidase Glutathione Testosterone Follicle Stimulating Hormone |
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