| 表面接枝处理的n-HA充填PLGA等温结晶行为的研究 |
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| 引用本文： | 蒋柳云,熊成东,李庆,白威,李玉宝. 表面接枝处理的n-HA充填PLGA等温结晶行为的研究[J]. 功能材料, 2011, 42(9) |
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| 作者姓名： | 蒋柳云 熊成东 李庆 白威 李玉宝 |
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| 作者单位： | 1. 中国科学院成都有机化学研究所,四川成都,610041
2. 四川大学分析测试中心 纳米生物材料研究中心,四川成都,610064 |
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| 摘 要： | 应用示差扫描量热计（DSC）研究了用低分子量聚乳酸（PDLLA）接枝与未接枝两种处理的纳米羟基磷灰石（n-HA）对聚乙丙交酯（PLGA）等温结晶行为及熔融行为的影响,采用Avrami方程处理其等温结晶过程,计算结晶动力学参数;同时用配带热台的偏光显微镜（POM）研究了其结晶的晶核形态。结果表明该体系等温结晶行为可以用Avrami方程来描述;加入n-HA的两种复合材料及PLGA其结晶最快的温度都是110℃,且都是随着结晶温度的提高结晶速率变慢,但接枝的n-HA对提高PLGA基体的结晶速率、熔点及结晶活化能都比未接枝处理的要小。偏光显微镜研究得出加入n-HA的两种复合材料及PL-GA其球径形态相似,且都随温度升高而使结晶速度降低,但加入未接枝的n-HA比接枝后的结晶更快。以上结果说明接枝处理后的n-HA提高了两相界面结合,因而n-HA的异相成核能力比未接枝处理的要差。
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| 关 键 词： | 聚乙丙交酯 纳米羟基磷灰石 表面接枝处理 等温结晶 结晶速率 |
Isothermal crystallization of PLGA filled with surface grafting treatment of n-HA |
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| JIANG Liu-yun,XIONG Cheng-dong,LI Qing,BAI Wei,LI Yu-bao. Isothermal crystallization of PLGA filled with surface grafting treatment of n-HA[J]. Journal of Functional Materials, 2011, 42(9) |
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| Authors: | JIANG Liu-yun XIONG Cheng-dong LI Qing BAI Wei LI Yu-bao |
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| Affiliation: | JIANG Liu-yun1,XIONG Cheng-dong1,LI Qing1,BAI Wei1,LI Yu-bao2(1.Chengdu Institute of Organic Chemistry,China Academy of Sciences,Chengdu 610041,China,2.Analytical and Testing Center,Sichuan University,Research Center for Nano-Biomaterials,Chengdu 610064,China) |
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| Abstract: | The influence of n-HA with surface grafted low molecular weight PDLLA on the isothermal rystallization and melting behaviour of PLGA were investigated by DSC.The Avrami equation had been used to analyze isothermal crystallization,and the correlative kinetics parameter values were given.Moreover,the crystal morphology of them were observed by a polarized optical microscopy(POM) with automatic hot-stage thermal unit.The results showed that the Avrami equation was suitable for describing the isothermal process... |
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| Keywords: | poly-lactic-co-glycolic acid nano-hydroxyapatite surface grafting treatment isothermal crystallization crystallization rate |
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