Lipid class distribution of fatty acids including conjugated linoleic acids in healthy and cancerous parts of human kidneys |
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Authors: | Kristina?Hoffmann J?rg?Blaudszun Claus?Brunken Wilhelm-Wolfgang?H?pker Roland?Tauber Email author" target="_blank">Hans?SteinhartEmail author |
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Affiliation: | (1) Department of Pathology, General Hospital Barmbek, 22291 Hamburg, Geramny;(2) Department of Urology, General Hospital Barmbek, 22291 Hamburg, Germany;(3) Institute of Biochemistry and Food Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany |
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Abstract: | In this study the FA compositions of healthy and cancerous human renal tissues from the same patients are compared with special
reference to the CLA and PUFA content. CLA was preferentially incorporated into neutral lipid compared with phospholipid classes.
Its distribution profile was similar to that of monounsaturated FA, but unlike that found with 18∶2n−6. Different incorporation
patterns were found for individual CLA isomers. Comparing renal cell carcinoma (RCC) and healthy kidney, the total CLA content
was significantly lower in the cholesterylester fraction and significantly higher in the PE and PS fractions from RCC. The
most significant differences between healthy and cancerous renal tissue were in the content of t10,c12-CLA. Furthermore, the lipid class distributions of n−6 PUFA were determined, and several significant differences between
RCC and healthy renal tissue were found. This is of interest, as it has been proposed that the anticarcinogenic properties
of dietary CLA are associated with their interference in the metabolism of 20∶4n−6. The involvement of CLA in preventing renal
cancer cannot be definitively demonstrated from the design of this study, nor was it intended, but the complete determination
of the FA composition of adjacent healthy and cancerous tissues may provide an insight if lipids are involved in this disease. |
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