Enantioselective Silylcyanation of Aldehydes and Ketones by a Titanium Catalyst Prepared from a Partially Hydrolyzed Titanium Alkoxide and a Schiff Base Ligand |
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Authors: | Kazuhiko Yoshinaga Takushi Nagata |
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Abstract: | In the presence of small amount (0.2–1.0 mol%) of a titanium complex catalyst prepared from a partially hydrolyzed titanium alkoxide and an optically active tridentate Schiff base ligand, the enantioselective silylcyanation of aldehydes and ketones proceeded in a short reaction time at room temperature to afford the corresponding optically active cyanohydrin derivatives in excellent chemical yield with high enantiomeric excess (86–97% ee). The results indicate that partially hydrolyzed titanium alkoxides are a promising titanium source for the preparation of efficient catalysts for asymmetric synthesis. |
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Keywords: | asymmetric catalysis cyanohydrins Schiff bases titanium water |
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