26例广岛原子弹爆炸受照者的染色体畸变分析

本研究工作是日本放射线影响研究所细胞遗传学研究方面有关工作的继续。对26名广岛原爆受照者(0—786rad)的染色体畸变的分析结果,发现畸变率与每一剂量组的平均剂量之间呈现良好的线性关系。大体看来,剂量每增加100rad,畸变细胞约增加3%,总畸变数约增加4%。对畸变类型的分析表明,大多数畸变为异常的单着丝点染色体,包括相互易位、倒位及缺失。它们约占总畸变数的86.3%。

THE CHROMOSOME ABERRATION ANALYSIS OF 26 CASES OF HIROSHIMA A-BOME SURVIVORS

The purpose of this study,which was a continuation of previousworks in RRFR,was to obtain more information about the relationship betweenchromosome aberration of A-bomb survivors and radiation dose and toexamine the predominant types of aberrations.By observing the aberrationsof 26 A-bomb survivors(0-786 rad),the results show that thefrequencies of aberrations in relation to the average dose of each groupfits well to a simple linear dose reponse model,Y=a bD.It seems that as the dose increased by 100 rad,the aberrant cells wouldincrease by 3% while the total aberrations by 4%,correspondingly.Theanalysis of the type of aberrations reveals that most of the aberrations wereabnormal monocentric chromosomes including translocations,inversions anddeletions,and they accounted for 86.3% of the total aberrations.