临床分离铜绿假单胞菌的耐药性研究

目的了解医院分离的铜绿假单胞菌感染分布及目前临床常用14种抗菌药物的耐药情况,指导临床合理选用抗菌药物。方法用K-B法分析2001~2004年间95株铜绿假单胞菌与14种常用抗生素的药敏性。结果实验菌株对14种抗菌药物都显示了较强的耐药率,其中对复方磺胺甲噁唑、四环素、氯霉素、环丙沙星、庆大霉素、左氧氟沙星、妥布霉素的耐药率均超过70%,且96.8%的菌株耐受3种以上抗菌药物。结论铜绿假单胞菌的耐药性突出。感染铜绿假单胞菌应在药敏实验指导下用药,治疗首选头孢他啶、阿米卡星或亚胺培南与氨基糖苷类联合治疗。

Study on Drug Resistance of Pseudomonas aeruginosa Clinical Isolates

Objective To instruct rational use of antibiotics in clinical practice by investigating the infection distribution of Pseudomonas aeruginosa clinical isolates and their drug resistance to 14 antibiotics commonly used.Methods A total of 95 Pseudomonas aeruginosa clinical isolates were collected during 2001~2004.Their drug resistance to 14 antibiotics was examined by Kirby-Bauer method.Results The clinical isolates showed strong drug resistance to some of 14 antibiotics.The frequencies of drug resistance to trimethoprim/sulfamethoxazole,tetracycline,chloramphenicol,ciprofloxacin,gentamicin,levofloxacin and tobramycin were all more than 70%.Furthermore,96.8% isolates were resistant to more than 3 antibiotics.Conclusion The problem of drug resistance is extensively existed in Pseudomonas aeruginosa clinical isolates.With the patients infected by Pseudomonas aeruginosa,it should be first treated empirically with ceftazidime,amikacin or the combination of imipenem and amInoglycosides.