手性CBS催化剂的研究进展

CBS催化剂是不对称还原反应中重要的手性催化剂，广泛应用于不对称合成领域中极重要的手性配体与手性中间体以及生物活性物质和天然物质的合成，具有巨大的市场潜力。CBS催化剂的制备通常是以(R/S)-脯氨酸为原料，先经某些反应保护氨基与羧基后进行格氏反应，之后脱去保护基团得前驱体(R/S)-α,α′-二苯基-2-吡咯烷甲醇，再与硼烷或其衍生物进行反应而得到。对CBS催化剂的制备方法、在有机合成中的应用、不对称催化反应的机理及其负载化进行了概述。

Latest researches in chiral CBS catalyst

CBS catalysts, as important chiral catalysts for asymmetric reduction, are widely used in asymmetric synthesis such as synthesis of chiral ligands, chiral intermediates, biologically-active materials and natural substance. CBS catalysts are usually prepared from (R/S)-proline, undergoing reactions for protection of the amino group and carboxyl group, Grignard reaction, removal of the  protected groups to obtain (R/S)-α,α′-diphenyl-2-pyrrolidinemethanolprecursor, and reaction of the precursor with borane or its derivatives. The preparation, application, reaction mechanism and immobilization of CBS catalysts were reviewed.