| 绿色氯化技术在农药中间体合成中的应用 |
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| 引用本文： | 杜晓华,任旭康,骆大为,葛林丹,许响生,陈瑨,严中杰,徐振元.绿色氯化技术在农药中间体合成中的应用[J].现代农药,2009,8(1):24-26. |
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| 作者姓名： | 杜晓华 任旭康 骆大为 葛林丹 许响生 陈瑨 严中杰 徐振元 |
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| 作者单位： | 浙江工业大学催化加氢研究中心,杭州,310014 |
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| 基金项目： | 浙江省绿色化工重大科技专项基金 |
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| 摘 要： | 盐酸-双氧水可替代液氯进行芳胺的亲电氯化,在农药中间体2,6-二氯-4-三氟甲基苯胺和4-氯-2-三氟甲基苯胺的合成上十分有效。双(三氯甲基)碳酸酯替代氯化亚砜、硫酰氯、三氯氧磷、五氯化磷、三氯化磷、光气等氯化剂,用于菊酰氯、苯甲酰氯、苯磺酰氯、氯代亚胺等农药中间体的合成。两种氯化方法的E因子显著小于传统方法。
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| 关 键 词： | 氯化 盐酸–双氧水 双(三氯甲基)碳酸酯 E因子 |
Application of Green Chlorination Techniques in the Synthesis of Pesticide Intermediates |
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| DU Xiao-hua,REN Xu-kang,LUO Da-wei,GE Lin-dan,XU Xiang-sheng,CHEN Jin,YAN Zhong-jie,XU Zhen-yuan.Application of Green Chlorination Techniques in the Synthesis of Pesticide Intermediates[J].Modern Agrochemicals,2009,8(1):24-26. |
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| Authors: | DU Xiao-hua REN Xu-kang LUO Da-wei GE Lin-dan XU Xiang-sheng CHEN Jin YAN Zhong-jie XU Zhen-yuan |
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| Affiliation: | Catalytic Hydrogenation Research Center;Zhejiang University of Technology;Hangzhou 310014;China |
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| Abstract: | HCl-H2O2 was used in the electrophilic chlorination of aromatic amines to replace liquid chlorine.Good results were obtained in the synthesis of 2,6-dichloro-4-trifluoromethylaniline and 4-chloro-2-trifluoromethylaniline.Bis(trichloromethyl)carbonate was applied in the synthesis of chrysanthemyl chloride,benzoyl chloride,benzesulfonyl chloride and imide chloride to replace such chlorination agents as thionyl chloride,sulfonyl chloride,phosphorusoxychloride,phosphorus pentchloride,phosphorus trichloride and ... |
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| Keywords: | chlorination HC1-H2O2 bis（trichloromethyl）carbonate E factor |
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