硝基甲苯的VNS氨化反应

以DMSO为溶剂，研究了在甲醇钠作用下，用4-氨基-1，2，4-三唑等对硝基甲苯的VNS氨化反应。结果表明，DNT氨化可以得到3-氨基-2，4-二硝基甲苯；而TNT氨化得到的是3，5-二氨基-2，4，6-三硝基甲苯（DATNT），两者的产率分别为10．5％和27．6%。当反应用微波加热时，氨化产物的转化率降低；而以盐酸羟胺作氨化试剂时，由TNT经过VNS氨化反应生成DATNT的产率不高。用红外光谱、核磁共振、元素分析和质谱签定了氨化产物的结构。

Amination of Nitrotoluenes via Vicarious Nucleophilic Substitution(VNS) of Hydrogen

The VNS amination reaction of nitrotoluene with ATA in DMSO in the presence of MeONa via vicarious nucleophilic substitution(VNS) of hydrogen was studied.The results indicated that 3-amino-2,4-dinitrotoluene was obtained by VNS amination of DNT in the yield of 10.5%,and 3,5-diamino-2,4,6-trinitrotoluene was obtained via VNS amination of 2,4,6-trinitrotoluene in the yield of 27.6%.The yields were lower under microwave radiation than that at room temperature.The amination of TNT in hydroxylamine gave DATNT in poor yield.The products were characterized by IR,nuclear magnetic resonance,elemental analyses and MS.