Effect of dietary vitamin C on adrenal cholesteryl ester content in the guinea pig |
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Authors: | Valerie A Wilbur Brian L Walker |
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Affiliation: | (1) Department of Nutrition, College of Biological Science, University of Guelph, N1G 2W1 Guelph, Ontario, Canada |
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Abstract: | Male guinea pigs fed a vitamin C-deficient diet for 3 weeks had lower concentrations of cholesteryl esters in their adrenals
than did control animals fed the recommended intake of the vitamin. Not all esters were affected to the same degree, and the
fatty acid profiles of the esters from control and deficient guinea pigs differed; there was proportionately more palmitic
and linoleic acids and less docosatetraenoic acid 22∶4 (n−6)] in the deficient guinea pig adrenal esters. Fatty acids are
designated as X∶Y (n−Z), where X and Y are the numbers of carbon atoms and olefinic bonds in the acid and Z is the number
of carbon atoms after the terminal olefinic bond.] A 100-fold excess of vitamin C in the diet also resulted in lower concentrations
of adrenal cholesteryl esters than did the control diet, but they were not as low as in the deficient animals. Fatty acid
profiles were similar for esters from control and excessively supplemented guinea pigs. Vitamin C deficiency apparently imposes
a long term stress which results in a depletion of adrenal cholesteryl esters, possibly specific esters, to meet the requirements
for glucocorticoid synthesis. |
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