Angiogenesis during tumor progression in the oral cavity is related to reduced apoptosis and high tumor cell proliferation |
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Authors: | D Ravi K Ramadas BS Mathew KR Nalinakumari MK Nair MR Pillai |
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Affiliation: | Institute for Biofunctional Research, Suita-City, Osaka, Japan. |
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Abstract: | To evaluate the potential of [1-(11)C]-3-(R,S)-methyloctanoate (BMOA), [1-(11)C]-2-octynoate, and [1-(11)C]-2-decynoate as PET tracers for studying particular steps in fatty acid beta-oxidation, we examined the pharmacokinetics of these compounds in rats and a cat. In rats given these compounds, high levels of radioactivity accumulated in the heart, liver, and kidneys, suggesting their potential as tracers for studying beta-oxidation in these tissues. These organs were clearly visible with PET in a cat given BMOA, indicating the utility of BMOA for imaging these organs. |
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