| 5-乙酰乙酰氨基苯并咪唑酮合成工艺研究 |
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| 引用本文： | 章振宇,张 静,申海蛟,马建宇,周立山,曲红梅. 5-乙酰乙酰氨基苯并咪唑酮合成工艺研究[J]. 化学工业与工程, 2014, 0(1): 24-27 |
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| 作者姓名： | 章振宇 张 静 申海蛟 马建宇 周立山 曲红梅 |
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| 作者单位： | 天津大学化工学院,天津300072 |
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| 基金项目： | 天津大学2012年大学生创新训练计划项目资助（201210056304）. |
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| 摘 要： | 以5-硝基苯并咪唑酮为原料,采用水合肼还原制备5-氨基苯并咪唑酮(BI),反应条件温和,安全,环境友好。研究了溶剂对BI合成5-乙酰乙酰氨基苯并咪唑酮(AABI)的影响:在乙酸乙酯中,BI与双乙烯酮反应合成AABI,收率可达89.3%。
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| 关 键 词： | 水合肼 还原 -氨基苯并咪唑酮 -乙酰乙酰氨基苯并咪唑酮 |
Synthesis of 5-Acetylacetamidobenzimidazolone |
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| Zhang Zhenyu,Zhang Jing,Shen Haijiao,Ma Jianyu,Qu Hongmei. Synthesis of 5-Acetylacetamidobenzimidazolone[J]. Chemical Industry and Engineering, 2014, 0(1): 24-27 |
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| Authors: | Zhang Zhenyu Zhang Jing Shen Haijiao Ma Jianyu Qu Hongmei |
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| Affiliation: | (School of Chemical Engineering and Technology, Tianjin University,Tianjin 300072, China) |
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| Abstract: | 5-aminobenzimidazolone was prepared from 5-nitrobenzimidazolone by hydrazine hydrate reduction. This method is mild, safe and environmentally friendly. The effect of solvents on the preparation of 5-acetylacetamidobenzimidazolone was studied. When ethyl acetate was used as solvent in this reaction, 5-acetylaeetamidobenzimidazolone was synthesized by the reaction of 5-amino benzimidazolone with diketene, the yield was 89.3%. |
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| Keywords: | hydrazine hydrate reduction 5-aminobenzimidazolone 5-acetylacetamidobenzimidazolne |
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