| 细胞骨架与辐射所致神经细胞迁移障碍研究进展 |
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| 引用本文： | 邱俊,吴翠萍,王明明.细胞骨架与辐射所致神经细胞迁移障碍研究进展[J].辐射防护,2012,32(3):165-170. |
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| 作者姓名： | 邱俊 吴翠萍 王明明 |
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| 作者单位： | 安徽医科大学放射医学研究所,合肥,230032 |
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| 基金项目： | 安徽省自然科学基金资助项目，安徽省教育厅自然科学基金资助项目 |
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| 摘 要： | 微管和微丝的动态变化是正常细胞迁移的主要动力。电离辐射引发机体组织和细胞的生物效应与细胞骨架的改变密切相关,辐射引起微丝解聚微管聚合障碍,使神经细胞无法进入迁移模式或迁移异常。本文综述了辐射所致细胞骨架改变对神经细胞迁移的影响。
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| 关 键 词： | 电离辐射 神经细胞迁移 微管 微丝 |
Progress of Research on Cytoskeleton and Neural Cell Migration Obstacle Induced by Ionizing Radiation |
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| Qiu Jun,Wu Cuiping,Wang Mingming.Progress of Research on Cytoskeleton and Neural Cell Migration Obstacle Induced by Ionizing Radiation[J].Radiation Protection,2012,32(3):165-170. |
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| Authors: | Qiu Jun Wu Cuiping Wang Mingming |
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| Affiliation: | (Institute of Radiation Medicine,Anhui Medical University,Hefei 230032) |
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| Abstract: | The dynamic changes of the microtubules and microfilaments provide the main force that drives the normal cell migration.Biological effects in tissues and cells induced by ionizing radiation are closely correlated with the changes happening to the cytoskeleton.It is that the ionizing radiation can induce the depolymeration of microfilaments and the assembly obstacles of microtubules,and make neural cell incapable of entering the model of migration or abnormally migrate.The effects of relevant changes of the cytoskeleton induced by irradiation on neural cell migration were discussed in this paper. |
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| Keywords: | ionizing radiation neural cell migration microtubules microfilaments |
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