低聚壳聚糖与银杏叶聚戊烯醇配伍对辐射损伤小鼠微核率及p53、Gadd45蛋白表达的影响

以低聚壳聚糖与不同浓度的银杏叶聚戊烯醇配伍,研究了其对受照小鼠30天存活率、存活时间、骨髓微核及脾脏p53、Gadd45蛋白的影响。结果表明,300 mg/kg低聚壳聚糖与5 mg/mg银杏叶聚戊烯醇配伍后能有效提高辐射损伤动物存活率和存活时间,降低损伤动物的微核率以及p53、Gadd45蛋白表达。说明低聚壳聚糖与银杏叶聚戊烯醇配伍具有一定的辐射损伤保护作用。

Study of Compatibility of Oligo-chitosan and Ginkgo Bilobal Polyprenol Influences on Micronuclear Rates and p53,Gadd45 Protein Expression of Radiated Mice

Study of compatibility of oligo-chitosan and ginkgo bilobal polyprenol(GP) influences on micronuclear rate and p53,gadd45 protein expression of radiated mice.Survival rate and survival time of 30-day-time of radiated mice was studied with the mixture of compatibility of oligo-chitosan and different density of GP.High survival rate of mixture density was screening.Another study on this mixture density was about micronuclear rates of marrow and p53,gadd45 protein of spleen after mice were radiated 12 h.The mixture of 300 mg/kg oligo-chitosan and 5 mg/kg GP could increase remarkably the survival rate and survival time of 30-day-time of radiated mice and degrade micronuclear rates and p53,gadd45 protein expression.Compatibility of oligo-chitosan and GP could effectively raise the survival rate of radiated mice.It could proved initially that the mixture has the function of radiation protection.