Frictional properties of light-activated antimicrobial polymers in blood vessels |
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Authors: | Polina Prokopovich Stefano Perni Clara Piccirillo Jonathan Pratten Ivan P Parkin Michael Wilson |
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Affiliation: | (1) Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Loughborough, LE11 3TU, UK;(2) Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Grays Inn Road, London, WC1X 8LD, UK;(3) Department of Chemistry, Materials Chemistry Research Centre, University College London, 20 Gordon Street, London, WC1H OAJ, UK; |
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Abstract: | The adhesion of microbes to catheter surfaces is a serious problem and the resulting infections frequently lead to longer
hospitalisation and higher risk for the patient. Several approaches have been developed to produce materials that are less
susceptible to microbial colonisation. One such approach is the incorporation of photoactivated compounds, such as Toluidine
Blue O (TBO), in the polymeric matrix resulting in ‘light-activated antimicrobial materials’. The insertion and removal of
catheters can cause tissue damage and patient discomfort through frictional forces; hence the lubricity of a catheter material
is also very important. In this work the tribological performance of silicone and polyurethane containing TBO and gold nanoparticles
were evaluated using two different surfaces, the inner part of the aorta and the superior vena cava of sheep. Static and kinetic
friction coefficients of these materials were measured using a tribometric device developed for in vitro applications using
dry materials and those lubricated with blood. It was found that neither the preparation process nor the presence of TBO or
gold nanoparticles, had an effect on the friction factors in comparison to those of untreated materials. In all cases, static
and kinetic friction coefficients on aorta tissue were higher than those on vena cava due to higher surface roughness of the
aorta. The presence of blood as a lubricant resulted in lower friction coefficients. |
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