The Importance of Small Extracellular Vesicles in the Cerebral Metastatic Process |
| |
| Authors: | Flaviu T&#x;ma&#x; Rodica B&#x;la&#x;a Doina Manu Gabriel Gyorki Rare&#x; Chinezu Corina T&#x;ma&#x; Adrian B&#x;la&#x;a |
| |
| Affiliation: | 1.University of Medicine, Pharmacy, Science and Technology “George Emil Palade”, 540142 Târgu Mureș, Romania; (F.T.); (R.B.); (R.C.); (A.B.);2.Department of Neurosurgery, Emergency Clinical County Hospital, 540136 Târgu Mureș, Romania;3.Department of Neurology, Emergency Clinical County Hospital, 540136 Târgu Mureș, Romania;4.Center for Advanced Pharmaceutical and Medical Research, 540139 Târgu Mures, Romania; |
| |
| Abstract: | Brain metastases represent more than 50% of all cerebral tumors encountered in clinical practice. Recently, there has been increased interest in the study of extracellular vesicles, and the knowledge about exosomes is constantly expanding. Exosomes are drivers for organotropic metastatic spread, playing important roles in the brain metastatic process by increasing the permeability of the blood–brain barrier and preparing the premetastatic niche. The promising results of the latest experimental studies raise the possibility of one day using exosomes for liquid biopsies or as drug carriers, contributing to early diagnosis and improving the efficacy of chemotherapy in patients with brain metastases. In this review, we attempted to summarize the latest knowledge about the role of exosomes in the brain metastatic process and future research directions for the use of exosomes in patients suffering from brain metastatic disease. |
| |
| Keywords: | brain small extracellular vesicles metastases exosomes oncoproteins cancer |
|
|
