Interactions between Radiation and One-Carbon Metabolism |
| |
| Authors: | Navyateja Korimerla Daniel R. Wahl |
| |
| Affiliation: | 1.Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA;2.Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA |
| |
| Abstract: | Metabolic reprogramming is a hallmark of cancer. Cancer cells rewire one-carbon metabolism, a central metabolic pathway, to turn nutritional inputs into essential biomolecules required for cancer cell growth and maintenance. Radiation therapy, a common cancer therapy, also interacts and alters one-carbon metabolism. This review discusses the interactions between radiation therapy, one-carbon metabolism and its component metabolic pathways. |
| |
| Keywords: | one-carbon metabolism radiation therapy cancer therapy folate cycle methionine cycle |
|
|
