液相色谱串联质谱法测定保健食品中西布曲明的不确定度

根据BJS 201701《食品中西布曲明等化合物的测定》对保健食品中西布曲明含量进行定量分析,采用JJF1059.1—2012《测量不确定度评定与表示》对液相色谱串联质谱法测定保健食品中西布曲明含量的不确定度进行评定。结果表明,95%的置信区间下,保健食品中西布曲明含量测定结果可表示为(7.04±0.197)μg/g,k=2,其中标准曲线拟合过程中引入的不确定度影响最大。

Uncertainty evaluation for determination of sibutramine in health foods by liquid chromatography-tandem mass spectrometry

To evaluate the uncertainty of the determination of sibutramine content in health foods by liquid chromatography-tandem mass spectrometry.Methods according to BJS 201701 Determination of sibutramine in food,and the content of sibutramine in health foods was detected.According to the approach in measurement uncertainty and results indication(JJF 1059.1-2012),the uncertainty was analyzed,quantified and synthesized.When sibutramine content was 7.04μg/g,the extended uncertainty was 0.197μg/g(k=2)under the 95%confidence interval.The main influence factors of the uncertainties in the determination were standard curve fitting process.