| 肼解还原法合成2,6-二氯-4-三氟甲基苯胺 |
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| 引用本文： | 兰艳娜,张华,徐强,李亚明,罗丽梅,丛丽英.肼解还原法合成2,6-二氯-4-三氟甲基苯胺[J].精细化工中间体,2005,35(4):30-32. |
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| 作者姓名： | 兰艳娜 张华 徐强 李亚明 罗丽梅 丛丽英 |
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| 作者单位： | 大连理工大学,精细化工国家重点实验室,辽宁,大连,116012;大连理工大学,精细化工国家重点实验室,辽宁,大连,116012;大连理工大学,精细化工国家重点实验室,辽宁,大连,116012;大连理工大学,精细化工国家重点实验室,辽宁,大连,116012;大连理工大学,精细化工国家重点实验室,辽宁,大连,116012;大连理工大学,精细化工国家重点实验室,辽宁,大连,116012 |
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| 摘 要： | 以3,4,5-三氯三氟甲苯为起始原料,经肼解、还原合成目的产物2,6-二氯-4-三氟甲基苯胺,总收率为81%。考察了溶剂、物料配比、反应温度和反应时间对肼解反应的影响,对目的产物采用红外光谱、1H核磁共振波谱、气相色谱/质谱进行结构鉴定,证明结构正确。
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| 关 键 词： | 2 6-二氯-4-三氟甲基苯胺 3 4 5-三氯三氟甲苯 肼解 结构表征 |
| 文章编号： | 1009-9212(2005)04-0030-03 |
| 收稿时间： | 2005-04-20 |
| 修稿时间： | 2005年4月20日 |
Synthesis of 2,6-Dichloro-4-Trifluoromethylaniline with Hydrazinolysis and Hydrogenolysis Reduction |
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| LAN Yan-na,ZHANG Hua,XU Qiang,LI Ya-ming,LUO Li-mei,CONG Li-ying.Synthesis of 2,6-Dichloro-4-Trifluoromethylaniline with Hydrazinolysis and Hydrogenolysis Reduction[J].Fine Chemical Intermediates,2005,35(4):30-32. |
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| Authors: | LAN Yan-na ZHANG Hua XU Qiang LI Ya-ming LUO Li-mei CONG Li-ying |
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| Abstract: | 2,6-dichloro-4-trifluoromethylphenylhydrazine was prepared by hydrazinolysis of 3,4,5-trichloro - benzotrifluoride with hydrazine hydrate, reduced by hydrogen gas with Raney Ni as catalyst to give 2,6-dichloro- 4-trifluoromethylaniline.Under the optimum condition the total yield of 2,6-dichloro-4-trifluoromethylphenylhy drazine was up to 81%. The effects of temperature, material mixture ratio and reaction time on the hydrazinolysis were also discussed. The structure of the compound was confirmed by spectral characterizations. |
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| Keywords: | 2 6-dichloro-4-trifluoromethylaniline 3 4 5-trichloro-benzotrifluoride hydrazinolysis characterization |
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