Potentiating effect of 5,8,11-eicosatrienoic acid on human platelet aggregation |
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Authors: | M Lagarde M Burtin H Sprecher M Dechavanne S Renaud |
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Affiliation: | 1. Unit 63, INSERM, 22 avenue du Doyen Lepiné, 69500, Bron, France 2. Institut Pasteur, Faculé Alexis Carrel Lyon, France 3. Department of Physiological Chemistry, Ohio State University, 43210, Columbus, OH 4. Laboratoire d'Hémobiologie, Faculté Alexis Carrel Lyon, France
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Abstract: | 5,8,11-Eicosatrienoic acid (20∶3ω9), a fatty acid increased in the platelet phospholipids of man and animals fed saturated fats, was either added to human platelets simultaneously with the aggregating agents, or incorporated into the platelet phospholipids by preincubation. 20∶3ω9 markedly increased the response of platelets to all aggregating agents tested when added simultaneously with the agent, but solely to thrombin and ionophore, after incorporation into the platelet phospholipids. The potentiating effects of 20∶3ω9 on thrombin aggregation do not appear to be related to prostaglandin formation, but rather to the production of a monohydroxy derivative through the lipoxygenase pathway. |
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