DNA binding of mixed-metal supramolecular Ru, Pt complexes |
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Authors: | Zhenglai Fang Shawn Swavey Alvin Holder Brenda Winkel Karen J. Brewer |
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Affiliation: | Department of Chemistry, Virginia Polytechnic Institute, Blacksburg, VA 24061-0212, USA |
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Abstract: | The mixed-metal supramolecular complexes [(tpy)Ru(PEt2Ph)(dpp)PtCl2](PF6)2 and [(tpy)Ru(PEt2Ph)(bpm)PtCl2](PF6)2 are of interest in that they couple light absorbing ruthenium centers to a reactive metal site through a communicative bridge (tpy=2,2′:6′,2′′-terpyridine, BPM=2,2′-bipyrimidine and DPP=2,3-bis(2-pyridyl)pyrazine). These systems have been studied and shown to avidly bind to DNA, greatly reducing its mobility through an agarose gel. |
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Keywords: | Supramolecular Ruthenium Platinum DNA binding Mixed-metal |
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