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| 干柱层析法分离中药藤黄中的新藤黄酸 | |
| 引用本文： | 刘卫海,赖小平,赵爱国,肖国丽. 干柱层析法分离中药藤黄中的新藤黄酸[J]. 广州化工, 2011, 39(7): 99-100 |
| 作者姓名： | 刘卫海 赖小平 赵爱国 肖国丽 |
| 作者单位： | 1. 广州中医药大学新药开发研究中心,广东广州,510006 2. 广州中医药大学新药开发研究中心,广东广州,510006;东莞广州中医药大学中医药数理工程研究院,广东东莞,523808 3. 广州中医药大学新药开发研究中心,广东广州,510006;清远医药集团,广东清远,511518;东莞广州中医药大学中医药数理工程研究院,广东东莞,523808 |
| 基金项目： | 广东省高等学校科技创新团队项目，广东省科技计划重点项目，东莞市科技计划高等院校和科研机构项目 |
| 摘 要： | 目的：分离中药藤黄中的新藤黄酸。方法：采用薄层硅胶G为固定相的干层析柱,以三氯甲烷-甲醇-二乙胺（10：1：1）为流动相进行洗脱,得到一黄色结晶。结果：采用UV,IR,MS,1HNMR和13CNMR方法获得该化合物波谱数据,经与文献报道数据对比,确定所分离得到的化合物为新藤黄酸。结论：干柱层析法可以快速有效地分离中药藤黄中的新藤黄酸。 |
| 关 键 词： | 干柱层析法 新藤黄酸 |
Neogambogic Acid Isolated from Gamboge with Dry Column Chromatography |
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| LIU Wei-hai,LAI Xiao-ping,ZHAO Ai-guo,XIAO Guo-li. Neogambogic Acid Isolated from Gamboge with Dry Column Chromatography[J]. GuangZhou Chemical Industry and Technology, 2011, 39(7): 99-100 | |
| Authors: | LIU Wei-hai LAI Xiao-ping ZHAO Ai-guo XIAO Guo-li |
| Affiliation: | 1 (1 New Drug R&D center,Guangzhou University of Chinese Medicine,Guangdong Guangzhou 510006;2 Qingyuan Medicine Group,Guangdong Qingyuan,511518;3 Dongguan Institution for Mathematics and Theoretics Engineering Research,Guangzhou University of Chinese Medicine,Guangdong Dongguan 523808,China) |
| Abstract: | The yellow crystal compound was obtained when silica gel G was used as the stationary phase in the dry chromatography column while chloroform-methanol-diethylamine(10:1:1) performed as the mobile phase.The results indicated that the structure of the acquired compound was identified by the UV,IR,MS,1HNMR and 13CNMR,according to compare with the related reference literature.This compound was confirmed as neogambogic acid.It was a easy method that the neogambogic acid could be quickly and effectively isolated from Gamboge by dry column chromatography. |
| Keywords: | dry column chromatography neogambogic acid |
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