| L-二苯甲酰酒石酸为拆分剂结晶拆分L,D-薄荷醇 |
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| 引用本文： | 苏圳,刘小波,吴学林,林小燕,念保义.L-二苯甲酰酒石酸为拆分剂结晶拆分L,D-薄荷醇[J].广州化工,2011,39(10):73-76. |
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| 作者姓名： | 苏圳 刘小波 吴学林 林小燕 念保义 |
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| 作者单位： | 三明学院化学与生物工程系,福建,三明,365004 |
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| 基金项目： | 福建省自然科学基金，福建省省属高校专项基金，福建省工业重点项目，福建省教育厅大学生科技创新项目 |
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| 摘 要： | 以L-酒石酸为原料,合成并纯化了结晶拆分剂L-二苯酒石酸;考察了L-二苯酒石酸结晶拆分过程的动力学控制,L-薄荷醇的收率提高23%。同时,研究了结晶拆分过程的溶剂影响。结果表明,用氯化锌代替氯化铁作为催化剂,L-二苯酒石酸的合成温度可降低12℃,重结晶纯化只需一次,可达到拆分剂的要求;L-二苯酒石酸结晶拆分消旋体薄荷醇喜好弱极性的组合溶剂（环己烷/水=80：20,V/V）,单一的高极性和非极性溶剂对结晶拆分不利。同时,展望了未来研究方向。
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| 关 键 词： | L-二苯酒石酸 结晶拆分 L-薄荷醇 溶剂效应 |
Racemic Menthol Resolution by Means of Crystallization with O,O'-dibenzoyl-(2R, 3R)-tartaric Acid as Resolving Agent |
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| SU Zhen,LIU Xiao-bo,WU Xue-lin,LIN Xiao-yan,NIAN Bao-yi.Racemic Menthol Resolution by Means of Crystallization with O,O'-dibenzoyl-(2R, 3R)-tartaric Acid as Resolving Agent[J].GuangZhou Chemical Industry and Technology,2011,39(10):73-76. |
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| Authors: | SU Zhen LIU Xiao-bo WU Xue-lin LIN Xiao-yan NIAN Bao-yi |
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| Affiliation: | (Department of Chemistry & Biology Engineering,Sanming University,Fujian Sanming 365004,China) |
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| Abstract: | O,O’-dibenzoyl-(2R,3R)-tartaric acid as crystallization resolving agent was systhesized for resolution racemate menthols from L-tartaric acid.The potential industrial application based on crystallization resolution to prepare the most important flavor,L-menthol,was investigated.The results were discussed by kinetics dominating of crystallization resolution.The optimal pathway of resolution was achieved by analyzing solvent efficient.Simultaneity,the future research direction was proposed from macro-kinetics of menthol resolution for the industrial processes. |
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| Keywords: | O O’-dibenzoyl-(2R 3R)-tartaric acid crystallization resolution L-menthol solvent efficient |
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