| 2-噻吩乙酸的合成 |
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| 引用本文： | 李长波,赵国峥,张洪林,蒋林时,邱峰.2-噻吩乙酸的合成[J].化学与生物工程,2007,24(4):22-23. |
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| 作者姓名： | 李长波 赵国峥 张洪林 蒋林时 邱峰 |
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| 作者单位： | 辽宁石油化工大学环境与生物工程学院,辽宁,抚顺,113001;辽宁石油化工大学环境与生物工程学院,辽宁,抚顺,113001;辽宁石油化工大学环境与生物工程学院,辽宁,抚顺,113001;辽宁石油化工大学环境与生物工程学院,辽宁,抚顺,113001;辽宁石油化工大学环境与生物工程学院,辽宁,抚顺,113001 |
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| 摘 要： | 在催化剂作用下,2-乙酰噻吩与过量的正丁胺反应生成乙酰噻吩-N-正丁胺,减压浓缩后直接在有机溶剂中与过量的硫反应得到N-丁基噻吩硫酰胺粗品,经浓缩、静置、过滤后在庚醇中氢氧化钠作用下发生水解,进一步酸化得到2-噻吩乙酸,总收率为46.5%.
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| 关 键 词： | 2-噻吩乙酸 2-乙酰噻吩 乙酰噻吩-N-正丁胺 N-丁基噻吩硫酰胺 合成 |
| 文章编号： | 1672-5425(2007)04-0022-02 |
| 修稿时间： | 2006-12-06 |
Synthesis of 2-Thiophene Acetic Acid |
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| LI Chang-bo,ZHAO Guo-zheng,ZHANG Hong-lin,JIANG Lin-shi,QIU Feng.Synthesis of 2-Thiophene Acetic Acid[J].Chemistry & Bioengineering,2007,24(4):22-23. |
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| Authors: | LI Chang-bo ZHAO Guo-zheng ZHANG Hong-lin JIANG Lin-shi QIU Feng |
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| Abstract: | 2-Thiophene acetic acid was synthesized through the following steps.2-Acetylthiophene was condensed with an excess of n-butylamine in the presence of catalyst so as to obtain acetylthiophene-N-n-butylamine.The concentrated imine was reacted with excess sulfur in organic solvent to produce N-butylthioamide.After concentration,depositing,filtration, the thioamide was hydrolyzed by the action of NaOH in heptanol and acidificated ulteriorly to liberate 2-thiophene acetic acid.The total yield of 2-thiophene acid was 46.5%. |
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| Keywords: | 2-thiophene acetic acid 2-acetylthiophene acetylthiophene N-n-butylamine N-butylthioamide synthesis |
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