The intestinal mucosa as a target for dietary polyunsaturated fatty acids |
| |
Authors: | A Donnet-Hughes E J Schiffrin M E Turini |
| |
Affiliation: | (1) Immunology Group Nestec Limited, Nestle Research Centre, Vers-chez-les-Blanc, P.O. Box 44, CH-1000 Lausanne 26, Switzerland;(2) Nutritional Sciences Group, Nestec Limited, Nestle Research Centre, Vers-chez-les-Blanc, P.O. Box 44, CH-1000 Lausanne 26, Switzerland |
| |
Abstract: | Several studies have reported beneficial effects of dietary polyunsaturated fatty acids (PUFA) on various aspects of both
human and animal health, and particular reference has been made to their effects on systemic immune responses. Both immune
stimulation and immune suppression have been reported, with the outcome dependent on the type of PUFA, the target cell, as
well as the immune competence of the cells before exposure. The systemic and the mucosal immune systems are discrete entities,
which have evolved specific approaches in the defense of the host. The latter comprises several interconnected tissues, which
communicate with one another through the action of soluble mediators and the trafficking of cellular components. After the
oral mucosa, the intestinal epithelium and its associated gutassociated lymphoid tissue are the primary targets of dietary
components. Absorption of dietary PUFA and its incorporation into intestinal tissues has been well studied, but the consequences
of these events in relation to local immune responses have received little attention. This article describes some of the immune
mechanisms operating at this barrier and, where possible, pinpoints areas for which a modulatory role for PUFA has already
been demonstrated. Although not an exhaustive treatise of the subject, it is hoped that this review will foster research into
the specific interaction between dietary PUFA and cell populations comprising the intestinal barrier. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|