马齿苋的多功效研究及安全性评价

以马齿苋作为研究对象,通过多种方法对其抑菌、美白、抗衰老、抗炎、抗敏等功效进行研究并对其安全性进行评价。结果显示,当马齿苋提取液质量浓度为125 g/L时,对5种常见菌均有抑制效果;质量浓度为2.0 g/L时,对酪氨酸酶的抑制率为82.49%,对DPPH自由基的清除率达100%,对羟自由基的清除率为92.56%,均高于同质量浓度的VC;质量浓度为150 g/L时,对小鼠耳廓肿胀抑制率为55.74%;质量浓度为1.5 g/L时,对透明质酸酶的体外抑制率为72.37%;质量浓度为200 g/L时,RBC溶血率为45.78%,半数溶血量为230 g/L;质量浓度不超过150 g/L的家兔急性眼刺激和人体安全性评价等级为安全无刺激。马齿苋具有较好的抑菌、美白、抗衰老、抗炎、抗敏功效,是一种安全无刺激的化妆品原料。

Study on functions of purslane and evaluation of its safety

Taking purslane as the research object, the study on its functions such as bacteriostatic, whitening, anti-aging, anti-inflammation and anti-allergy, and evaluation of its safety were carried out through a variety of methods. Results show that when the mass concentration of purslane extract is 125 g/L, it can inhibit five kinds of common bacteria. When the mass concentration is 2.0 g/L, the inhibition rate of tyrosinase is 82.49%, the scavenging rate of DPPH radical is 100%, and the scavenging rate of hydroxyl radical is 92.56%, all higher than the same mass concentration of vitamin C. When the mass concentration is 150 g/L, the mice auricle swelling inhibition rate is 55.74%. When the mass concentration is 1.5 g/L, the inhibition rate of hyaluronidase in vitro is 72.37%. When the mass concentration is 200 g/L, the RBC hemolytic ratio is 45.78%, and the half hemolytic dose is 230 g/L. Results of acute eye irritation test of rabbits and human safety rating are safe and non-irritating, when the mass concentration is not exceeded 150 g/L. Purslane has good bacteriostatic, whitening, anti-aging, anti-inflammatory, and anti-allergic functions, is a safe and non-irritating cosmetics raw materials.