| 高效液相色谱法测定化妆品中硝酸咪康唑的含量 |
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| 引用本文： | 郭春梅,矫筱蔓,张伏,庞燕军,陆军,赵晓冬.高效液相色谱法测定化妆品中硝酸咪康唑的含量[J].香料香精化妆品,2012(4):27-29. |
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| 作者姓名： | 郭春梅 矫筱蔓 张伏 庞燕军 陆军 赵晓冬 |
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| 作者单位： | 辽宁省食品药品检验所,辽宁沈阳,110023 |
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| 摘 要： | 建立了化妆品中硝酸咪康唑含量的高效液相色谱检测方法。样品经甲醇-三氯甲烷(1∶1)超声提取,用高效液相色谱分离后,采用二极管阵列检测器进行检测。方法检出限为10 ng,定量限为35 ng,在5～150μg/mL范围内线性良好(R=0.9992),三个浓度水平的加标回收率在90%～110%之间,精密度RSD为0.18%,重复性RSD小于5%。该方法简便、快速、精密度高、实用性好,能够满足化妆品中硝酸咪康唑含量测定的要求。
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| 关 键 词： | 高效液相色谱法 硝酸咪康唑 化妆品 |
Determination on the Content of Miconazole Nitrate in Cosmetics by HPLC |
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| GUO Chunmei
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JIAO Xiaoman
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ZHANG Fu
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PANG Yanjun
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LU Jun
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ZHAO Xiaodong.Determination on the Content of Miconazole Nitrate in Cosmetics by HPLC[J].Flavour Fragrance Cosmetics,2012(4):27-29. |
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| Authors: | GUO Chunmei JIAO Xiaoman ZHANG Fu PANG Yanjun LU Jun ZHAO Xiaodong |
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| Affiliation: | (The Institute for Food and Drug Control of Liaoning Province,Shenyang 110023,Liaoning,China) |
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| Abstract: | A HPLC method for determination the content of miconazole nitrate in cosmetics was established.The sample was ultrasonically extracted by methanol-trichloromethane（1/1）,then detected by HPLC-DAD.The limit of detection for miconazole nitrate was 10 ng,the limit of quantification for miconazole nitrate was 35 ng,at the spiked levels of 5-150 μg/mL（R=0.9992）.The mean recoveries were 90%-110%,with the precision 0.18%,repeatability were less than 5%.The method was simple and fast with high precision and good practicability,suitable for the determination of the content of miconazole nitrate in cosmetics. |
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| Keywords: | HPLC miconazole nitrate cosmetics |
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