Bioinspired Diselenide‐Bridged Mesoporous Silica Nanoparticles for Dual‐Responsive Protein Delivery |
| |
Authors: | Dan Shao Mingqiang Li Zheng Wang Xiao Zheng Yeh‐Hsing Lao Zhimin Chang Fan Zhang Mengmeng Lu Juan Yue Hanze Hu Huize Yan Li Chen Wen‐fei Dong Kam W Leong |
| |
Affiliation: | 1. Department of Biomedical Engineering, Columbia University, New York, NY, USA;2. CAS Key Laboratory of Bio Medical Diagnostics, Suzhou Institute of Biomedical, Engineering and Technology, Chinese Academy of Sciences, Suzhou, China;3. Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun, China;4. Department of Systems Biology, Columbia University, New York, NY, USA |
| |
Abstract: | Controlled delivery of protein therapeutics remains a challenge. Here, the inclusion of diselenide‐bond‐containing organosilica moieties into the framework of silica to fabricate biodegradable mesoporous silica nanoparticles (MSNs) with oxidative and redox dual‐responsiveness is reported. These diselenide‐bridged MSNs can encapsulate cytotoxic RNase A into the 8–10 nm internal pores via electrostatic interaction and release the payload via a matrix‐degradation controlled mechanism upon exposure to oxidative or redox conditions. After surface cloaking with cancer‐cell‐derived membrane fragments, these bioinspired RNase A‐loaded MSNs exhibit homologous targeting and immune‐invasion characteristics inherited from the source cancer cells. The efficient in vitro and in vivo anti‐cancer performance, which includes increased blood circulation time and enhanced tumor accumulation along with low toxicity, suggests that these cell‐membrane‐coated, dual‐responsive degradable MSNs represent a promising platform for the delivery of bio‐macromolecules such as protein and nucleic acid therapeutics. |
| |
Keywords: | biodegradable mesoporous silica nanoparticles cancer‐cell‐membrane cloaking diselenide dual‐responsive protein delivery |
|
|