Two‐Dimensional Antimonene‐Based Photonic Nanomedicine for Cancer Theranostics |
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| Authors: | Wei Tao Xiaoyuan Ji Xianbing Zhu Li Li Junqing Wang Ye Zhang Phei Er Saw Wenliang Li Na Kong Mohammad Ariful Islam Tian Gan Han Zhang Morteza Mahmoudi Guillermo J. Tearney Omid C. Farokhzad |
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| Affiliation: | 1. Center for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA;2. School of Pharmaceutical Sciences (Shenzhen), Sun Yat‐sen University, Guangzhou, China;3. School of Life Sciences, Tsinghua University, Beijing, China;4. Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;5. Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China;6. Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics, SZU–NUS Collaborative Innovation Center for Optoelectronic Science and Technology, and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen, China |
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| Abstract: | Antimonene (AM) is a recently described two‐dimensional (2D) elemental layered material. In this study, a novel photonic drug‐delivery platform based on 2D PEGylated AM nanosheets (NSs) is developed. The platform's multiple advantages include: i) excellent photothermal properties, ii) high drug‐loading capacity, iii) spatiotemporally controlled drug release triggered by near‐infrared (NIR) light and moderate acidic pH, iv) superior accumulation at tumor sites, v) deep tumor penetration by both extrinsic stimuli (i.e., NIR light) and intrinsic stimuli (i.e., pH), vi) excellent multimodal‐imaging properties, and vii) significant inhibition of tumor growth with no observable side effects and potential degradability, thus addressing several key limitations of cancer nanomedicines. The intracellular fate of the prepared NSs is also revealed for the first time, providing deep insights that improve cellular‐level understanding of the nano–bio interactions of AM‐based NSs and other emerging 2D nanomaterials. To the best of knowledge, this is the first report on 2D AM‐based photonic drug‐delivery platforms, possibly marking an exciting jumping‐off point for research into the application of 2D AM nanomaterials in cancer theranostics. |
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| Keywords: | antimonene cancer theranostics drug delivery nanomedicine two‐dimensional nanosheets |
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